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Abacavir hydroxyacetate

CAS No. 1446418-48-9

Abacavir hydroxyacetate( —— )

Catalog No. M33097 CAS No. 1446418-48-9

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Abacavir hydroxyacetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor.
  • Description
    Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems.
  • In Vitro
    ——
  • In Vivo
    Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice.Animal Model:6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue Dosage:10 and 20 mg/kg Administration:Oral gavage; 10-20 mg/kg once Result:Decreased the concentration of PRINS and 1L-20, and reduced the lesion area of skin. Showed a better effect than methotrexate in controlling psoriasis.
  • Synonyms
    ——
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIV Protease
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1446418-48-9
  • Formula Weight
    344.37
  • Molecular Formula
    C16H20N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (290.39 mM)
  • SMILES
    Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](COC(=O)CO)C=C3)c2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis - potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939.?
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